孟凤华,教授,博导。www.优德88.cpm 生物医用高分子材料重点实验室骨干成员、全球高被引学者(Clarivate Analytics,2018-2022)、中国高被引学者、欧洲研究理事会(ERC)Consolidator Grant特聘会评专家(2020年—)、沙特阿拉伯研究开发与创新局(RDIA)评审专家、美国控制释放协会(CRS)会员。
她于1995年大连理工大学化工学院高分子化工专业获学士学位,1998年中国科学院长春应用化学研究所高分子化学与物理专业获理学硕士学位(导师:黄葆同院士),2003年荷兰屯特大学(University of Twente)高分子化学和生物材料专业获理学博士学位(导师:Jan Feijen教授)。2005-2007年在荷兰屯特大学生物医学技术研究所从事博士后研究。2007年受聘为www.优德88.cpm 副教授,2010年晋升为教授、博士生导师。
孟凤华教授在国际主流期刊如Adv. Mater.、Angew.Chem.-Int. Edit.、Signal Transduct. Tar.、J. Control. Release、Bioact. Mater.、Biomaterials等上发表了180多篇同行评审文章(引用次数> 22000次,H指数:78),并编撰了三本书的章节。她已申请国内外发明专利> 75件,授权60余件(11件专利已转让)。获得苏州市科技进步奖二等奖和江苏省科技进步奖二等奖各一次;两篇论文获得“中国百篇最具影响国际学术论文”、两次苏州市自然科学优秀学术论文一等奖等奖项。她担任Drug Delivery and Translational Research、Exploration of Medicine期刊的编委;还担任过CRS 2019年会组会委员及Biomacromolecules(2024年)和Frontiers in Pharmacology(2022年)特刊的客座编辑。主持了十余项国家级研究项目,包括国自然重点项目、国际合作项目、面上项目以及公司合作项目。
研究领域:
纳米药物、肿瘤靶向治疗、蛋白质和核酸药物的靶向递送、刺激响应性胶束和聚合物体、癌症免疫疗法、生物医用高分子
代表性论文:
1. J.Y. Wang, B.B. Guo, Z.W. Sun, S.S. Zhao, L. Cao, Z.Y. Zhong*, and F.H. Meng*, Polymersomal poly(I:C) self-magnifies anti-tumor immunity by simultaneously inducing immunogenic cell death and systemic immune activation, Adv. Healthcare Mater. 2024, doi.org/10.1002/adhm.202400784.
2. B.B. Guo, Y. Qu, Y.P. Sun, S.S. Zhao, J.D. Yuan, Z.Y. Zhong*, and F.H. Meng*, Co-delivery of gemcitabine and paclitaxel plus NanoCpG empowers chemoimmunotherapy of “cold” triple-negative breast cancer, Bioact. Mater. 2023, 25, 61-72.
3. Y.P. Sun#, Y.J. Sha#, G.H. Cui, F.H. Meng*, Z.Y. Zhong*, Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy, Adv. Drug Deli. Rev. 2023, 192,114624.
4. Y.F. Xia#, J.N. An#, J.Y. Li, W.X. Gu, Y.F. Zhang, S.S. Zhao, C.Z. Zhao, Y. Xu*, B. Li, Z.Y. Zhong*, F.H. Meng*, Transferrin-Guided Intelligent Nanovesicles Augment the Targetability and Potency of Clinical PLK1 Inhibitor to Acute Myeloid Leukemia, Bioactive Mater. 2023, 21, 499-510.
5. W.C. Yan, B.B. Guo, Z. Wang, J.T. Yang, Z.Y. Zhong*, and F.H. Meng*, RGD-directed 24 nm micellar docetaxel enables elevated tumor-liver ratio, deep tumor penetration and potent suppression of solid tumors, J. Control. Release. 2023, 4, 304-315.
6. D.W. Ni#, B.B. Guo#, Zhangyan Zhong, Yu Chen, G. Yang, J.T. Yang, Z.Y. Zhong*, and F.H. Meng*, Integrin-targeting disulfide-crosslinked micellar docetaxel eradicates lung and prostate cancer patient-derived xenografts, Acta Biomater. 2023, 170, 228-239.
7. R. Huang, Hong Du. L. Cheng, P.Z. Zhang, F.H. Meng*, Z.Y. Zhong*, Targeted nanodelivery of siRNA against KRAS G12D inhibits pancreatic cancer, Acta Biomater. 2023, 168, 529-539.
8. R. Huang, F.F. Wang, H. Fu, X.M. Qi, G.Z. Xing, J. Ren*, L. Cheng, F.H. Meng*, Z.Y. Zhong*, Bioresponsive Chimaeric Polymersomes Mediate Sustained and Liver-Specific siRNA Transfection In Vivo, Biomacromolecules 2023, 24 (11), 5353-5363
9. L. Yang, Y.J. Sha, Y.S. Wei, H.H. Fang, J.J. Jiang, L.C. Yin and Z.Y. Zhong*, F.H. Meng*, Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy, Biomate. Sci. 2023, 11 (6), 2211-2220.
10. J.J. Wei#, D. Wu#, S.S. Zhao, Y. Shao, Y.F. Xia, D.W. Ni, X.Y. Qiu, J.P. Zhang, J. Chen*, F.H. Meng*, Z.Y. Zhong*, Immunotherapy of Malignant Glioma by NonInvasive Administration of TLR9 Agonist CpG Nano-immunoadjuvant. Adv.Sci. 2022, 9, 2103689.
11. J.J. Wei, D. Wu, Y. Shao, B.B. Guo, J.J. Jiang, J. Chen, J.P. Zhang, F.H. Meng*, Z.Y. Zhong*, ApoE-Mediated Systemic Nanodelivery of Granzyme B and CpG for Synergistic Glioma Immunotherapy. J. Control. Release, 2022, 347,68-77
12. H. Zheng, B.B. Guo, X.Y. Qiu, Y.F. Xia, Y. Qu, L. Cheng*, F.H. Meng*, Z.Y. Zhong*, Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy, Bioact. Mater., 2022, 16, 1-11.
13. J.J. Jiang#, R.X. Wang#, L. Yang, Y.J. Sha, S.S. Zhao, J.X. Guo, D.F. Chen*, Z.Y. Zhong*, F.H. Meng*, IL-11Rα-targeted nanostrategy empowers chemotherapy of relapsed and patient-derived osteosarcoma xenografts in mice, J. Control. Release. 2022, 350, 460-470.
14. X.Y. Qiu, Y. Qu, B.B. Guo, H. Zheng, F.H. Meng*, Z.Y. Zhong*, Micellar Paclitaxel Boosts ICD and Chemo-Immunotherapy of Metastatic Triple Negative Breast Cancer, J. Control. Release, 2022, 341, 498-510. (Special issue, invited)
15. B.B. Guo, J.J. Wei, J.Y. Wang, Y.P. Sun, J.D. Yuan, Z.Y. Zhong*, and F.H. Meng*, CD44-targeting hydrophobic phosphorylated gemcitabine prodrug nanotherapeutics augment lung cancer therapy, Acta Biomater. 2022, 145, 200-209.
16. H.H. Fang, Y.J. Sha, L. Yang, J.J. Jiang, L.C. Yin, J.Y. Li, B. Li, B. Klumperman, Z.Y. Zhong*, and F.H. Meng*, Macrophage-targeted hydroxychloroquine nanotherapeutics for rheumatoid arthritis therapy, ACS Appl. Mater. Interfaces. 2022, 14, 8824-8837.
17. Z. Wang, S.S. Zhao, J. Shi, F.H. Meng*, J.D. Yuan, Z.Y. Zhong*, Folate-mediated targeted PLK1 inhibition therapy for ovarian cancer: A comparative study of molecular inhibitors and siRNA therapeutics, Acta Biomater.2022, 138, 443-452.
18. Z. Wang, B.B. Guo, S.J. Yue, S.S. Zhao, F.H. Meng*, Z.Y. Zhong*, HER-2-mediated nano-delivery of molecular targeted drug potently suppresses orthotopic epithelial ovarian cancer and metastasis. Int. J. Pharm. 2022, 625, 122126.
19. L. Yang, H.H. Fang, J.J. Jiang, Y.J. Sha, Z.Y. Zhong*, and F.H. Meng*, EGFR-Targeted Pemetrexed Therapy of Malignant Pleural Mesothelioma, Drug Deliv Transl Res 2022, 12 (10), 2527-2536.
20. S.P. Cao#, Y.F. Xia#, J.X. Shao, B.B. Guo, Y.Y. Dong, I.A.B. Pijpers, Z.Y. Zhong, F.H. Meng*, L.K.E.A. Abdelmohsen*, D.S. Williams*, and J.C.M. van Hest,* Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy, Angew. Chem. Int. Ed., 2021, 60, 17629-17637.
21. Y.F. Xia, J.J. Wei, S.S. Zhao, B.B. Guo, F.H. Meng*, Bert Klumperman, Z.Y. Zhong*, Systemic administration of polymersomal oncolytic peptide LTX-315 combining with CpG adjuvant and anti-PD-1 antibody boosts immunotherapy of melanoma, J. Control. Release 2021, 336, 262–273.
22. Y.H. Wei#, Y.P. Sun#, J.J. Wei, X.Y. Qiu, F.H. Meng*, G. Storm*, J.D. Yuan, Z.Y. Zhong*, Selective Transferrin Coating as a Facile Strategy to Fabricate BBB-Permeable and Targeted Vesicles for Potent RNAi Therapy of Brain Metastatic Breast Cancer in Vivo, J. Control. Release 2021, 337, 521-529.
23. W.X. Gu#, R.B. Qu#, F.H. Meng*, J.J.L.M. Cornelissen, and Z.Y. Zhong*, Polymeric Nanomedicines Targeting Hematological Malignancies, J. Control. Release, 2021, 337, 571-588.
24. W.X. Gu, F.H. Meng*, and Z.Y. Zhong*, Actively Targeted Nanomedicines for Precision Cancer Therapy: Concept, Construction, Challenges and Clinical Translation J. Control. Release, 2021, 329, 676-695.
25. W.X. Gu, T.H. Liu, D.Y. Fan, J.B. Zhang, XY.F. Xia, F.H. Meng*, Y. Xu*, J.J.L.M. Cornelissen, Z.J. Liu, and Z.Y. Zhong*, A6 peptide-tagged, ultra-small and reduction-sensitive polymersomal vincristine sulfate as a smart and specific treatment for CD44+ acute myeloid leukemia, J. Control. Release, 2021, 329, 706-716.
26. Z. Wang, S.S. Zhao, W.X. Gu, Y.Y. Dong, F.H. Meng*, J.D. Yuan, Z.Y. Zhong*, Alpha 3 integrin binding peptide-functionalized polymersomes loading PLK1 inhibitor volasertib for dually targeted molecular therapy of ovarian cancer in vivo Acta Biomater. 2021, 124, 348-357.
27. J.J. Wei, Y.F. Xia, F.H. Meng*, D.W. Ni, X.Y.Qiu, Z.Y. Zhong*, Small, Smart and LDLRs-Specific Micelles Augment Sorafenib Therapy of Glioblastoma, Biomacromolecules 2021, 22, 11, 4814-4822.
28. Y.H. Wei, X.L. Gu, Y.P. Sun, F.H. Meng*, G. Storm*, Z.Y. Zhong*, Transferrin-Binding Peptide Functionalized Polymersomes Mediate Targeted Doxorubicin Delivery to Colorectal Cancer In Vivo, J. Controlled Release 2020, 319, 407-415.
29. Y.N. Zhong, F.H. Meng*, W. Zhang, B. Li, J.C.M. van Hest, Z.Y. Zhong,* CD44-Targeted Vesicles Encapsulating Granzyme B as Artificial Killer Cells for Potent Inhibition of Human Multiple Myeloma Xenografts in Mice, J. Controlled Release, 2020, 320, 421-430.
30. C. Zhou#, Y.F. Xia#, Y.H. Wei, L. Cheng*, J.J. Wei, B.B. Guo, F.H. Meng*, S.P. Cao, J.C.M. van Hest, Z.Y. Zhong*, GE11 Peptide-Installed Chimaeric Polymersomes Tailor-Made for High-Efficiency EGFR-Targeted Protein Therapy of Orthotopic Hepatocellular Carcinoma, Acta Biomater. 2020, 113, 512-521.
31. Y. Zou#, Y.P. Sun#, Y.H. Wei, Y.F. Xia, Z.Y. Huangfu, F.H. Meng*, J.C.M. van Hest, J.D. Yuan, Z.Y. Zhong*, a3b1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutics for Non-Small Cell Lung Cancer Treatment, ACS Appl. Mater. Interfaces 2020, 12, 14905-14913.
32. Y.W. Li#, J.J. Wei#, Y.H. Wei, L. Cheng*, B.B. Guo, F.H. Meng*, F. Li, Z.Y. Zhong*, Apolipoprotein E Peptide-Guided Disulfide-Crosslinked Micelles for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma, Biomacromolecules. 2020, 21, 716-724.
33. W.X. Gu#, J.N. An#, H. Meng, N. Yu, Y.N. Zhong, F.H. Meng*, Y. Xu*, J.J.L.M. Cornelissen, and Z.Y. Zhong*, CD44-Specific A6 Short Peptide Boosts Targetability and Anticancer Efficacy of Polymersomal Epirubicin to Orthotopic Human Multiple Myeloma, Adv. Mater. 2019, 31, 1904742.
34. Y. Zou#, Y.H. Wei#, Y.P. Sun, J. Bao, F.R. Yao, Z.K. Li, F.H. Meng*, C.H. Hu, G. Storm, Z.Y. Zhong*, Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Tumor, Theranostics 2019, 9 (26), 8061-8072.
35. Y.H. Wei, X.L. Gu, L. Cheng*, F.H. Meng*, G. Storm, Z.Y. Zhong*, Low-Toxicity Transferrin-Guided Polymersomal Doxorubicin for Potent Chemotherapy of Orthotopic Hepatocellular Carcinoma in Vivo, Acta Biomater. 2019, 92, 196-204.
36. Y. Zou, J.J. Wei, Y.F. Xia, F.H. Meng*, J.D. Yuan, Z.Y. Zhong*, Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin, Signal Transduct. Tar. 2018, 3: 32.
37. W.J. Yang, Y. F. Xia, Y. Fang, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, Z.Y. Zhong*, Selective cell penetrating peptide-functionalized polymersomes mediate efficient and targeted delivery of methotrexate disodium to human lung cancer in vivo,Adv. Healthc. Mater. 2018, 7(7), 1701135.
38. W.J. Yang, L. Yang, Y.F. Xia, L. Cheng*, J. Zhang, F.H. Meng*, J.D. Yuan, Z.Y. Zhong*, Lung cancer specific and reduction-responsive chimaeric polymersomes for highly efficient loading of pemetrexed and targeted suppression of lung tumor in vivo, Acta Biomater. 2018, 70, 177-185.
39. L. Cheng, L. Yang, F.H. Meng*, Z.Y. Zhong*, Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy, Adv. Healthc. Mater. 2018, 7, 1800685. Invited paper.
40. W.J. Yang, Y.H. Wei, J. Zhang, Z.Y. Zhong*, F.H. Meng*, Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo, J. Control. Release 2018, 290, 141-149. invited paper.
41. Y. Zou, Y.F. Xia, F.H. Meng*, J. Zhang, Z.Y. Zhong*, GE11-Directed Functional Polymersomal Doxorubicin as an Advanced Alternative to Clinical Liposomal Formulation for Ovarian Cancer Treatment, Mol. Pharm. 2018, 15, 3664-3671. Invited paper
42. J.J. Wei, H. Meng, B.B. Guo, Z.Y. Zhong*, F.H. Meng*, Organocatalytic ring-opening copolymerization of trimethylene carbonate and dithiolane trimethylene carbonate: Impact of organocatalysts on copolymerization kinetics and copolymer microstructures, Biomacromolecules 2018, 19, 2294-2301. Invited paper.
43. I.A.B. Pijpers, L.K.E.A. Abdelmohsen, Y.F. Xia, S.P. Cao, D.S. Williams, F.H. Meng*, J.C.M. van Hest*, Z.Y. Zhong*, Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies, Adv. Therapeutics 2018, 1(8), 1800068.
44. Y. Zou#, M. Zheng#, W.J. Yang, F.H. Meng*, K. Miyata, H.J. Kim, K. Kataoka*, Z.Y. Zhong*, Virus-Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo,Adv. Mater. 2017, 29, 1703285.
45. Y. Zou#, Y.H. Wei#, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017, 29, 1603997.
46. W.J. Yang, Y.F. Xia, Y. Zou, F.H. Meng*, J. Zhang, Z.Y. Zhong*, Bioresponsive chimaeric nano-polymersomes enable targeted and efficacious protein therapy for human lung cancers in vivo, Chem. Mater., 2017,29,8757-8765.
47. Y. Fang, W.J. Yang, L. Cheng*, F.H. Meng*, Jian Zhang, Z.Y. Zhong*, EGFR-targeted multifunctional polymersomal doxorubicin induces selective and potent suppression of orthotopic human liver cancer in vivo,Acta Biomater. 2017, 64,323-333.
48. Y. Fang, Y. Jiang, Y. Zou, F.H. Meng*, J. Zhang, C. Deng, H.L. Sun and Z.Y. Zhong*, Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(e-caprolactone) micelles, Acta Biomater. 2017, 50,396-406.
49. H. Meng, Y. Zou, P. Zhong, F.H. Meng*, J. Zhang, R. Cheng, and Z.Y. Zhong*, A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability and Fast Responsive Drug Release for Targeted Cancer Therapy, Macromol. Biosci. 2017, 17 (10) 1600518. (invited article).
50. N. Zhang, Y.F. Xia, Y. Zou, W.J. Yang, J. Zhang, Z.Y. Zhong*, and F.H. Meng*, ATN-161 Peptide Functionalized Reversibly Crosslinked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice, Mol. Pharm. 2017, 14(8), 2538-2547 (invited article).
51. Y.N. Zhong; F.H. Meng*, C. Deng, X.L. Mao*, Z.Y. Zhong*, Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles. Drug delivery; 2017, 24(1), 1482-1490.
52. C.F. Hang#, Y. Zou#, Y.N. Zhong, Z.Y. Zhong*, F.H. Meng*, NIR and UV-Responsive Degradable Hyaluronic Acid Nanogels for CD44-Targeted and Remotely Triggered Intracellular Doxorubicin Delivery, Colloids Surf. B: Biointerfaces 2017, 158 (1), 547-555.
53. W.J. Yang, Y. Zou, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, and Z.Y. Zhong*, Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimaeric polymersomes, Adv. Mater. 2016, 28 (37), 8234-8239.
54. Y.N. Zhong, K. Goltsche, L. Cheng, F. Xie, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo, Biomaterials 2016, 84, 250-261.
55. Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Robust, Tumor-Homing and Redox-Sensitive Polymersomal Doxorubicin: A Superior Alternative to Doxil and Caelyx? J. Control. Release 2016, 239, 149-158.
56. Y. Zou, Y. Fang, H. Meng, F.H. Meng*, C. Deng, J. Zhang and Z.Y. Zhong*, Self-Crosslinkable and Intracellularly Decrosslinkable Biodegradable Micelles: A Robust, Simple and Multifunctional Nanoplatform for High-Efficiency Targeted Cancer Chemotherapy, J. Control. Release 2016, 244,326-335.
57. Y.N. Zhong, M. Dimde, D. Stöbener, F.H. Meng*, C. Deng, Z.Y. Zhong*, R. Haag, Micelles with Sheddable Dendritic Polyglycerol Sulfate Shells Show Extraordinary Tumor Targetability and Chemotherapy In Vivo, ACS Appl. Mater. Interfaces 2016, 8, 27530-27538.
58. X. Li, W.J. Yang, Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J. Control. Release 2015, 220, 704-714.
59. L. Lu, Y. Zou, W.J. Yang, F.H. Meng*, C. Deng, R. Cheng, and Z.Y. Zhong*, Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells, Biomacromolecules 2015, 16, 1726-1735.
60. H.L. Sun, R. Cheng, C. Deng, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Enzymatically and Reductively Degradable a-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules 2015, 16, 597-605.
61. J.L. Lv, H.L. Sun, Y. Zou, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen and Z.Y. Zhong*, Reduction degradable amino acid-based poly-(ester amide)-graft-galactose copolymers: facile synthesis, self-assembly, and hepatoma targeting doxorubicin delivery. Biomater. Sci. 2015, 3, 1134-1146.
62. Y.N. Zhong, C. Wang, R. Cheng, L. Cheng, F.H. Meng*, Z. Liu*, Z.Y. Zhong*, and R. Haag, cRGD-Directed, NIR-Responsive and Robust AuNR/PEG-PCL Hybrid Nanoparticles for Targeted Chemotherapy of Glioblastoma In Vivo, J. Control. Release 2014, 195, 63-71.
63. Y. Zou, Y. Song, W.J. Yang, F.H. Meng*, H. Y. Liu, and Z.Y. Zhong*, Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice, J. Control. Release 2014, 193, 154-161
64. F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, Z.Y. Zhong*, pH-Sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances, Nanomedicine, 2014, 9, 487-499 (invited review)
65. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction and pH dual-bioresponsive crosslinked polymersomes for efficient intracellular delivery of proteins and potent induction of cancer cell apoptosis. Acta Biomater. 2014, 10, 2159-2168
66. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, 21, 755-767 (invited review)
67. W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171–179.
68. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction-sensitive degradable micellar nanoparticles as smart and intuitive delivery systems for cancer chemotherapy. Expert Opinion on Drug Delivery 2013, 10, 1109-1022. (invited review)
69. X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier to Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells. Biomacromolecules, 2013, 14, 2873–2882
70. Y.D. Gu, Y.N. Zhong,F.H. Meng*,R. Cheng,C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules, 2013, 14, 2772–2780
71. F.H. Meng, R. Cheng, C. Deng, Z.Y. Zhong*, Intracellular Drug Release Nanosystems, Mater. Today 2012, 15, 436-442. (invited review)
72. F.H. Meng, and Z.Y. Zhong*,Polymersomes Spanning from Nano to Micro Scales: Advanced Vehicles for Controlled Drug Delivery and Robust Vesicles for Virus and Cell-Mimicking,J. Phys. Chem. Letters 2011, 2, 1533-1539. (Invited Perspective)
73. G.J. Liu, S.B. Ma, S.K. Li, R. Cheng, F.H. Meng*, H.Y. Liu, Z.Y. Zhong*, The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes, Biomaterials 2010, 31, 7575-7585.
74. W. Chen, F.H. Meng*, R. Cheng, and Z.Y. Zhong*, pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release 2010, 142, 40-46.
75. W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng*, W.X. Wei, and Z.Y. Zhong*, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Postpolymerization Modification via Michael-Type Addition Reaction, Macromolecules 2010, 43, 201–207.
76. C.H. Zhu, S.Y. Jung, G.Y. Si, R. Cheng, F.H. Meng*, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection, J. Polym. Sci. Part A: Polym. Chem. 2010, 48, 2869–2877.
77. H.L. Sun, F.H. Meng*, B.N. Guo, X.Q. Li, R. Cheng, H.Y. Liu, and Z.Y. Zhong*, Shell-sheddable micelles based on dextran-ss-poly(e-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin, Biomacromolecules 2010, 11, 848–854.
78. Y.L. Li, L. Zhu, Z.Z. Liu, R. Cheng, F.H. Meng*, J.H. Cui, S.J. Ji, and Z.Y. Zhong*, Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells, Angew. Chem. Int. Ed. 2009, 48, 9914-9918.
79. H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng*, H.Y. Liu, Z.Y. Zhong*, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin, Biomaterials 2009, 30, 6358-6366.
80. H.F. Xu, F.H. Meng*, Z.Y. Zhong*, Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release, J. Mater. Chem. 2009, 19: 4183-4190.
81. Y.M. Xu, F.H. Meng*, R. Cheng, Z.Y. Zhong*, Reduction-Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin, Macromol. Biosci. 2009, 9, 1254-1261.
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